ANSWER: DESI and DESI XS are not supported on Xevo TQ-S or Xevo TQ-XS. The DESI source is supported only on select Waters QTof instruments and the TQ Absolute.
SYMPTOMS: No signal or low signal from the DESI source on red or black markers Small amount of LeuEnk signal may be visible from spray ESI Signal OK Noise observed on the Tune page Voltage readbacks a...SYMPTOMS: No signal or low signal from the DESI source on red or black markers Small amount of LeuEnk signal may be visible from spray ESI Signal OK Noise observed on the Tune page Voltage readbacks appear correct No or little erosion of the Sharpie pen marks
CAUSE: Blocked sprayer tip
FIX: Rebuild the DESI sprayer, replacing the tip. DESI XS - DESI XS HP Sprayer Emitter Cartridge - part number 700013110 Prosolia DESI sprayer - Taper tip emitter 5 pack - part number 700010778
OBJECTIVE: Remove the DESI XS source from a Xevo TQ-XS instrument.
PROCEDURE: (The procedure is similar for other mass spectrometers.) Verify that the MS is in Standby and the API gas is off. Cool dow...OBJECTIVE: Remove the DESI XS source from a Xevo TQ-XS instrument.
PROCEDURE: (The procedure is similar for other mass spectrometers.) Verify that the MS is in Standby and the API gas is off. Cool down the ion block, setting it to 30 degrees and then shut down MassLynx and the camera viewer software. Turn off the DESI XS using the power button located on the back of the source (If DESI XS Source is removed completely and not stacked on top of the Xevo TQ-XS, you might need to disconnect all four
ANSWER: The DESI source option is supported on Xevo G2-XS, Xevo G3, SYNAPT G2-Si, Synapt XS and Xevo TQ Absolute Xevo G2-S and SYNAPT G2-S do not support the DESI source.
OBJECTIVE: Acquire a desorption electrospray ionization (DESI) image on a SYNAPT XS or Xevo G2-XS.
PROCEDURE: Perform instrument setup (detector setup and calibration), preferably using the ESI-Locksp...OBJECTIVE: Acquire a desorption electrospray ionization (DESI) image on a SYNAPT XS or Xevo G2-XS.
PROCEDURE: Perform instrument setup (detector setup and calibration), preferably using the ESI-Lockspray source enclosure. Install the DESI XS source as described in WKB254643. Configure the inlet file as described in section 4.7.1 ("Changing the inlet method") of the DESI XS Ion Source Overview and Maintenance Guide. Select a target slide (e.g., 700012809 Slide 26 mm x 76 mm or 700012675 Large sli
OBJECTIVE: Install or uninstall a DESI XS source enclosure.
PROCEDURE: Installing the DESI XS Source Set instrument to Standby Open the vacuum tab on the Tune Page to monitor the backing pressure. Clo...OBJECTIVE: Install or uninstall a DESI XS source enclosure.
PROCEDURE: Installing the DESI XS Source Set instrument to Standby Open the vacuum tab on the Tune Page to monitor the backing pressure. Close the ion block isolation valve, remove the cone gas nozzle, and transfer the sample cone (including the O-ring) to the HTL (heated transfer line). Install the HTL, open the isolation valve, and directly check if the backing vacuum is approximately 3 mbar. Note: If backing pressure exceeds 4.5 mbar