"Desolvation temperature failed to settle" error appears between all samples - WKB54794

SYMPTOMS

• "Desolvation temperature failed to settle" error message
• When the run stops, desolvation temperature readback in the tune page regulates to the set value
• Found: MS method is set up for polarity switching
• Found: Desolvation temperatures for ES+ and ES- modes in the Tune page are different

ENVIRONMENT

• All Waters quadrupole and triple quadrupole instruments
• Xevo TQD
• Xevo TQ-S
• Xevo TQ-S micro
• Xevo TQ-XS
• ACQUITY QDa Detector
• Xevo G2-S
• Xevo G2-XS
• SYNAPT G2-S
• Xevo G2 Tof
• Xevo G2 QTof

CAUSE

In the Tune page, the setting for desolvation temperature is different in positive and negative modes, causing problems when using positive/negative switching in the acquisition method.

FIX or WORKAROUND

1. MS method is intended for Pos/Neg switching
   • Open the Tune page and ensure that the desolvation temperature setting is the same for positive and negative modes. (Also verify that the source temperature and gas flow settings are the same in both modes.)
   • Save the tune page. 
2. MS method is not intended for Pos/Neg switching
   • Open the MS Method
   • Review all functions in the method and verify that they are all set to the same ion mode
   • If they are not, correct those which are not to the appropriate ion mode

ADDITIONAL INFORMATION