For running the mass spectrometer at high flow rates, what are recommended flow rates versus temperature and gas flow? - WKB204351

ENVIRONMENT

• Mass spectrometer
• MassLynx
• UNIFI
• Xevo TQ MS
• Xevo TQD
• Xevo TQ-S
• Xevo TQ-S cronos
• Xevo TQ-S micro
• Xevo TQ-XS
• SQ Detector 2

ANSWER

The Acquity UPLC system runs at high flow rates. When optimizing desolvation and thus sensitivity, appropriate gas flows and desolvation temperatures are needed. Intellistart Software automatically sets these parameters when you enter a flow rate, according to the following table.  

Find information in the Operators Overview and Maintenance Guide for each particular instrument in the Waters Support Library. This information is also in the MassLynx Help file.

For example:

Xevo TQ-XS Mass Spectrometry - Overview and Maintenance Guide:

ADDITIONAL INFORMATION

At higher flow rates, capillary voltage may need to be reduced and probe position may need to be adjusted away from the cone. Notice: If you position the probe too close to the sample cone, nonlinear data, sample suppression, and the need for frequent source cleaning can result. 

How to optimize for either ESI or APcI using ESCI with intellistart - WKB9654

How to tune up for APCI or ESCI mode - WKB7804