Is Windows 10 supported with MassLynx 4.2? - WKB1709

ENVIRONMENT

MassLynx 4.2

Microsoft Windows 10 Enterprise Long-Term Servicing Channel (LTSC) 2021 (64-bit) 

Microsoft Windows 10 Long Term Servicing Branch (LTSB) Build 1607

ANSWER

MassLynx 4.2 is supported on Windows 10.

All currently shipping MS instruments are now supported with Windows 10 Enterprise LTSC 2021 (on Waters supplied Lenovo P520 and P720 only) with the latest software release.
Note: the release notes might not reflect the updated support for the newer Windows version. For more details choose your MS from this article:
What is the latest version of MassLynx Software that supports my MS instrument? - WKB554 - Waters

All currently shipping instruments are supported with Windows 10 Long Term Servicing Branch (LTSB) Build 1607.

Selected 'legacy' instruments are supported with Windows 10 Long Term Servicing Branch (LTSB) Build 1607:

SQD, 3100, TQD - SCN 989　
AutoSpec Premier - SCN 992　
SYNAPT G2-S, MALDI SYNAPT G2-S, SYNAPT G2-Si, MALDI SYNAPT G2-Si - SCN 1003
SYNAPT G2, MALDI SYNAPT G2 - SCN 991
Xevo G2-S QTof, Xevo G2-S Tof   - SCN 971　
Xevo G2 QTof, Xevo G2 Tof  - SCN 990 　
Xevo TQ MS - SCN 986

Legacy i​nstruments not in this list are not supported on Windows 10.

ADDITIONAL INFORMATION

Browse for your instrument via What is the latest version of MassLynx Software that supports my MS instrument? - WKB554 for the latest MassLynx 4.2 software and release notes etc. for your instrument

For clarity: 
The initially released MassLynx 4.2 SCNs were supported on both Windows 7 and Windows 10 Enterprise LTSB 1607. 
Microsoft support for Windows 7 has ended so Windows 7 support will no longer be included in new MassLynx releases.