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Waters

Unstable spray on Xevo instruments during infusion - WKB16868

Article number: 16868

SYMPTOMS

  • Unstable spray during infusion
  • Peaks blink off and on

ENVIRONMENT

  • Xevo TQ MS
  • Xevo TQD
  • Xevo TQ-S
  • Xevo TQ-S micro
  • Xevo TQ-XS
  • SQD2
  • Xevo QTof
  • Xevo Tof
  • Xevo G2 QTof
  • Xevo G2 Tof
  • Xevo G2-S
  • Xevo G2-S QTof
  • Xevo G2-S Tof
  • Xevo G2-XS
  • Xevo G2-XS QTof
  • Xevo G2-XS Tof

CAUSE

Incorrect Tune page settings for desolvation gas and temperature

FIX or WORKAROUND

  1. Adjust desolvation gas flow for low flow (e.g., <500 L/h for 10 µL/min).
  2. Adjust desolvation temperature for low flow (e.g., <200 °C for 10 µL/min).

ADDITIONAL INFORMATION

If the desolvation temperature is too high, the solvent will evaporate prior to leaving the capillary, thereby killing the electrospray effect.

 

ESI

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