Poor QTof resolution on intact proteins or monoclonal antibodies (mAb) - WKB115197
Article number: 115197
SYMPTOMS
- Poor resolution on intact proteins or monoclonal antibodies
ENVIRONMENT
- Xevo QTof
- Xevo G2 QTof
- Xevo G2-S
- Xevo G2-XS
- Synapt HDMS
- SYNAPT G2-S
- SYNAPT G2-Si
- Vion IMS QTof
- ACQUITY RDa
- BioAccord
CAUSE
Salt residues in source - The presence of Na or K creates adducts, resulting in a complicated spectrum.
FIX or WORKAROUND
Replace the sample cone with a new one.
ADDITIONAL INFORMATION
As an alternative action, increasing the cone gas flow rate may reduce the negative effect on the intact protein envelop. See the related KCS article WKB117940.