Skip to main content

How to reboot a Xevo series quadrupole MS (MassLynx) - WKB1075

Article number: 1075


Reboot the system to re-establish communication after a power outage.


  • MassLynx
  • Xevo TQD
  • SQ Detector 2
  • Xevo TQ MS
  • Xevo TQ-S
  • Xevo TQ-S micro
  • Xevo TQ-XS


  1. Exit any open MassLynx or console windows.
  2. Power-off the UPLC components, but not the MS.
  3. Restart the MassLynx computer.
  4. Log into Windows, but do not open MassLynx.
  5. Power-on the component that has the Ethernet hub (Column manager if there is one otherwise Sample Manager).
  6. Power-on the remaining UPLC components.
  7. Insert a piece of PEEK tubing into the reset hole on the front of the MS and press the reset switch.
  8. Wait for the status lights on all components to be green or unlit.
  9. Open MassLynx.
  10. Open the tune page.
  11. Select Vacuum > Pump to start the pump-down.


If this reboot is unsuccessful, repeat the steps above, but power-off the MS if it is vented (step 2) and, after logging into Windows (step 4), open the Waters DHCPserverconfiguration.exe and remove all components, power-on as in steps 5 and 6, and, instead of step 7, power-on the MS . Watch the components populate all columns in the Waters DHCPserverconfiguration window. Continue with steps 9 through 11.

Not able to find a solution? Click here to request help.