Calculation of USP Signal-to-Noise Ratio - Tip201

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Tip #201: Calculation of USP Signal-to-Noise Ratio

The previous tip (Tip #200) discussed a question about identifying peaks in Empower.  

This tip discusses the calculation of USP signal-to-noise ratio.

ENVIRONMENT

• Empower

PROCEDURE

1. The result displayed does not have the USP signal-to-noise (s/n) nor the USP Noise calculated.
   
    
2. The ‘Suitability’ tab in the Processing Method shows the correct selection for calculating USP signal-to-noise (s/n) and the use of a blank injection to calculate noise.
   
    
3. Working backwards, ‘Alter Sample Set’ displays the ‘Sample Matrix’ field.  The problem is the selection for the ‘Blank’ is different from the rest of the samples.
   
    
4. Modify the ‘Sample Matrix’ to the same as the blank.
   
    
5. Reprocess the Sample Set and now the result for the same sample shows the values are calculated.
   
    
6. Search on ‘Verifying System Performance’ in the online help and you will see a Tip regarding the Sample Matrix.
   

ADDITIONAL INFORMATION

Final Note: Refer to Tip #28 and Tip #30 for more detail on calculating signal-to-noise (s/n) ratio