How to calculate USP and EP signal to noise in Empower - WKB1123

ENVIRONMENT

• Empower 2
• Empower 3
• Regional Pharmacopoeia
• Customer must be in compliance with USP

ANSWER

• In Empower, select the Suitability tab and click "Calculate USP, EP, and JP s/n" (signal-to-noise).
• Select "Use noise centered on peak region in blank region".  Leave Half Height Multiplier with default values.
• In the Alter Sample window (or Sample Set Method), indicate in "Blank" column which injection(s) to assign as the blank for noise calculations.
• Process data.
• View peak field USP s/n accordingly.

ADDITIONAL INFORMATION

 TECN134884650 - Signal-to-Noise Values in Empower 3

 TECN1852625 - Understanding the EP Signal to Noise Calculation in Empower 2

Tip #30: Calculating signal-to-noise ratio (Part 3)

https://blog.waters.com/get-empowere...em-suitability