Low sensitivity on a triple quad MS - WKB9577

SYMPTOMS

• Low sensitivity in MRM mode
• Setup solution when infusing looks as expected

ENVIRONMENT

• Xevo TQD
• Xevo TQ-S
• Xevo TQ-XS
• Xevo TQ-S Micro
• TQD
• Xevo TQ MS
• Quattro Premier/XE
• Quattro Micro

CAUSE

Solvents expired—mobile phases and customer extraction and spiking solutions

FIX or WORKAROUND

1. Use fresh solvents.
2. Make up fresh spiking and extraction solutions per customer SOPs.
3. Prime and run blanks.

ADDITIONAL INFORMATION