How to calibrate a time-of-flight (TOF) mass spectrometer up to 4000 m/z - WKB8507

OBJECTIVE or GOAL

Calibrate TOF MS up to 4000 m/z.

ENVIRONMENT

• Time-of-flight (TOF) mass spectrometer

PROCEDURE

1. Infuse NaI or NaCsI.
2. Inspect the Scope view in the Tune page to look for large NaI or NaCsI clusters approaching 4000 m/z.
3. You may need to increase cone gas flow to increase mass transmission up to 4000 m/z (gas flow of 250 or higher may be necessary).
4. You may need to increase cone voltage to increase mass transmission up to 4000 m/z  (cone voltage of 100 or higher may be necessary).

ADDITIONAL INFORMATION