- Spectral valleys are too high on Intact Protein analysis
- Valleys are >50%
- Xevo G2-XS
Solvent purity/contamination problem
FIX or WORKAROUND
- Use solvents and additives known to be clean.
- Run a number of injections to clean impurities from the system.
The solvent/additive mixture should be renewed as often as possible to avoid loss of system performance due to potential pH changes, auto-oxidative, and/or photolytic degradation within the solvent bottle.