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Waters

Valleys too high for Intact Protein analysis on a Xevo G2-XS - WKB26943

Article number: 26943

SYMPTOMS

  • Spectral valleys are too high on Intact Protein analysis
  • Valleys are >50%

ENVIRONMENT

  • Xevo G2-XS

CAUSE

Solvent purity/contamination problem

FIX or WORKAROUND

  1. Use solvents and additives known to be clean.
  2. Run a number of injections to clean impurities from the system.

ADDITIONAL INFORMATION

The solvent/additive mixture should be renewed as often as possible to avoid loss of system performance due to potential pH changes, auto-oxidative, and/or photolytic degradation within the solvent bottle.

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