Low sensitivity with Xevo TQ-S due to contaminated ACQUITY UPLC - WKB11015
Article number: 11015
SYMPTOMS
- Low system sensitivity
- Sensitivity with setup solution is good
- Sensitivity when running LC-MS runs is low
ENVIRONMENT
- Xevo TQ-S
- Xevo TQ-XS
- Xevo TQ MS
CAUSE
The ACQUITY UPLC has become contaminated, leading to ion suppression and thus much lower signals.
FIX or WORKAROUND
Clean the UPLC using the acid/base cleaning protocol.
If 20 injections of acid/base/IPA do not improve then run 100 injections of acid/base/IPA
ADDITIONAL INFORMATION
To investigate contamination on a triple quad, it can be helpful to run a full-scan MS Run instead of an MRM.
id11015, isopropanol, XEVOG2XSQT, XEVOTQ, XEVOTQA, XEVOTQIVD, XEVOTQS, XEVOTQSCRO, XEVOTQSIVD, XEVOTQSMIC, XEVOTQXS, XEVTQSMIVD, XEVTQXSIVD