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Low sensitivity with Xevo TQ-S due to contaminated ACQUITY UPLC - WKB11015

Article number: 11015

SYMPTOMS

  • Low system sensitivity
  • Sensitivity with setup solution is good
  • Sensitivity when running LC-MS runs is low

ENVIRONMENT

  • Xevo TQ-S
  • Xevo TQ-XS
  • Xevo TQ MS

CAUSE

The ACQUITY UPLC has become contaminated, leading to ion suppression and thus much lower signals. 

FIX or WORKAROUND

Clean the UPLC using the acid/base cleaning protocol.

If 20 injections of acid/base/IPA do not improve then run 100 injections of acid/base/IPA

ADDITIONAL INFORMATION

To investigate contamination on a triple quad, it can be helpful to run a full-scan MS Run instead of an MRM.

id11015, isopropanol, XEVOG2XSQT, XEVOTQ, XEVOTQA, XEVOTQIVD, XEVOTQS, XEVOTQSCRO, XEVOTQSIVD, XEVOTQSMIC, XEVOTQXS, XEVTQSMIVD, XEVTQXSIVD

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