How to clean the cone on a Waters Mass Spectrometer - WKB10984

Article number: 10984

OBJECTIVE or GOAL

Clean the sample cone and cone gas nozzle when the following conditions apply:

The sample cone and cone gas nozzle are visibly fouled/dirty.
You have dismissed LC and sample-related causes for decreased signal intensity.
Consider cleaning the sample cone and cone gas nozzle on a routine basis depending on MS usage.

Follow the maintenance procedures in the relevant MS Operator's Overview and Maintenance Guide for safety precautions and materials required.

Remove the sample cone assembly following the procedure in the relevant MS Operator's Overview and Maintenance Guide.
Remove the o-ring (and the PEEK handle if present) from the sample cone.
Place the cone and sample cone nozzle on their flat base in a clean glass beaker/vessel (never on the tip as it can damage the cone) containing 1:1 methanol:water.
If the components are visibly contaminated, use 45:45:10 methanol/water/formic acid.
Place the beaker/vessel in an ultrasonic bath for 30 minutes.
If using formic acid in the cleaning solution, rinse with water and place in a glass beaker with 100% water.
Place the beaker/vessel in an ultrasonic bath for 20 minutes.
Remove any residual water from components by putting them in a glass beaker/vessel with 100% methanol.
Place the beaker/vessel in an ultrasonic bath for 10 minutes.
Carefully remove the components from the glass beaker and blow dry them with inert, oil-free gas.

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