Can I use NMP (N-methyl-2-pyrrolidinone) with the 2695 Separations Module? - WKB90831

ENVIRONMENT

• 2695 Separations Module

ANSWER

1.Can I use if it is a THF-compatible degasser?
Yes. NMP can be pumped through a THF-compatible degasser. However, a compatible pump head is also required.
For 2695, it is necessary to change the pump head seal to the clear seal (700001326: seal, clear, 2 pack, Alliance).
See the KCS article at the end of this document for details.

2. Can I use without using THF-compatible parts?
No. NMP is not compatible with regular seals. See Appendix D of the Alliance e2695 Separations Module Operator's Guide (see URL below)
https://www.waters.com/waters/support.htm?lid=10091556&type=USRM

3. Can I use as an Autosampler cleaning solution?
Not recommended.

4. Can I use as a sample dilution solvent?
Yes.

NMP can be used on the 2695 with THF-compatible parts. See this article for more information.
How do I make the Alliance 2695 compatible with normal phase solvent, such as THF? - WKB4337
https://support.waters.com/KB_Inst/Chromatography/WKB4337_How_do_I_make_the_Alliance_2695_compatible_with_normal_phase_solvent_such_as_THF

ADDITIONAL INFORMATION