Negative peaks observed using Refractive Index Detector - WKB67342
Article number: 67342
SYMPTOMS
- Negative peaks observed using Refractive Index Detector
- Negative peaks have the same peak shape and intensity as positive peaks, but they appear mirrored
- Reduce back pressure does not resolve
- Occurring in both standard and samples
- Noise and drift test pass, but peak integration is not consistent.
ENVIRONMENT
- 2410 Differential Refractometer
- 2414 Refractive Index Detector
- ACQUITY RI Detector
CAUSE
The cell is dirty
FIX or WORKAROUND
- Clean the sample and reference cell as described in the Refractive Index Detector Overview and Maintenance Guide. See the section "Decontaminating the fluidics path".