Increased response, peaks in blanks - WKB241078

SYMPTOMS

• Increased response for one or more analytes
• Analyte is showing up in blanks
• SM and BSM diagnostics pass

ENVIRONMENT

• ACQUITY UPLC
• ACQUITY UPLC H-Class
• ACQUITY UPLC H-Class Bio
• ACQUITY UPLC I-Class
• ACQUITY UPLC H-Class PLUS
• ACQUITY UPLC H-Class PLUS Bio
• ACQUITY UPLC I-Class PLUS
   
• ACQUITY TQD system
• TQ Detector
• Xevo TQ MS
• Xevo TQD
• Xevo TQ-S
• Xevo TQ-S micro
• Xevo TQ-XS

CAUSE

Poor sample preparation with potentially contaminated solvents

FIX or WORKAROUND

1. Prepare new samples or standards using all new solvent bottles. 
2. If a new plate does not fix the issue, perform a system flush (Poor Inter-Instrument Reproducibility, Unstable Areas, High Baseline, Poor Peak Shape, or Unexpected Peaks - wkb234708), putting on new mobile phases afterwards.

ADDITIONAL INFORMATION