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How to qualify a system with a second detector when using SQT - WKB12732

Article number: 12732

OBJECTIVE or GOAL

Qualify a system with a second detector when using SQT.

ENVIRONMENT

  • ACQUITY UPLC Systems with multiple detectors.
  • Empower SystemsQT (Systems Qualification Tool).

PROCEDURE

There are many cases where a customer has a system with more than one detector. Follow this protocol if the qualification project does not contain both detectors in the system configuration.

  1. Create a system in Empower with the primary detector and perform the full suite of system qualification tests on that primary detector.  
  2. Create a system in Empower with the secondary detector plumbed in series and rerun the SQT, selecting only the OQ tests appropriate to the second detector. (This includes the system precision test.)

ADDITIONAL INFORMATION

  • Keep tubing lengths as short as possible between the primary and secondary detectors.
  • Adjust retention times in the processing methods. A single detector SQT does not account for the extra volume.
  • Any changes to the processing method require a comment when saving and must be documented in the SQT documentation.

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