Instrument status is "Not available" with AB Sciex Analyst and ACQUITY H-Class - WKB3828

SYMPTOMS

• When user tries to start any method, the status shows the system as "Not available". See screen shot below:

• Under regedit: HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Waters\Instruments\ACQ-AAO\ServiceSettings > the SerializedObjects is missing.

ENVIRONMENT

• Analyst 1.6.2 with Windows 7, 64 bit
• ACQUITY H-Class
• Waters Driver Pack 4 Supplemental Release 1 (DP4SR1)

CAUSE

An incompatible security mode is being used with Analyst DP4 SR1 (v1.65).

Driver Pack 4 Supplemental Release 1 (DP4SR1) is not compatible with Integrated mode.

FIX or WORKAROUND

1. Switch from Integrated mode (which uses the Windows login) to Mixed mode (which requires a login to Analyst and the ACQUITY method editor).
2. To check the security mode:

a. Log in to Analyst.

b. Click on Configure.

c. Click on Security contents, and then click More.

d. Check the modes.

ADDITIONAL INFORMATION

There are three security modes available in Analyst software:

1. Mixed mode - requires a login to Analyst each time and a one-time (per user) login to ACQUITY control

2. Integrated mode - uses the Windows login and does not require additional login to Analyst or ACQUITY control

3. Single-user mode - turns security off. No login and no user-specified roles or privileges