Use of 50 different concentration levels in TargetLynx - WKB60731

SYMPTOMS

• Quantifying more than 20 analytes in TargetLynx or QuanLynx
• Concentration column goes only to "Conc T"

ENVIRONMENT

• TargetLynx
• QuanLynx
• MassLynx 4.1 and 4.2

CAUSE

MassLynx was originally designed to allow up to 20 different concentrations of standards at a time.

FIX or WORKAROUND

SCN 997 introduced the ability to use the Mass fields in the same way as the Conc A-T fields are used. There is a total of 30 Mass fields in the sample list, Mass A-Z plus Mass AA-Mass DD. 

This makes it possible to use a total of 50 different concentration levels in TargetLynx in all releases of MassLynx 4.2 for the Quads since SCN 997. 

ADDITIONAL INFORMATION

Previous Workaround, for older SCNs:
If multiple compounds are spiked into one stock and that stock is diluted to create multiple curves, the "Stock Concentration Factor" can be used.

1. Open the TargetLynx or QuanLynx processing method.
2. Click the Calibration Properties tab for your analyte.
3. Under "Concentration of Standard: Level", pick one of the concentration columns (for example, Conc A).
4. Select the check box for "Stock Concentration Factor".
5. Specify the concentration of the stock for your analyte.
6. On the sample list of your main MassLynx page, put the dilution factor for each level of your calibration curve under the "Conc x" column chosen in step 3.
7. All of the analytes in the combined stock can use the same Concentration column, because the standards will be diluted the same way.

MassLynx 4.2 SCN 997 for the Xevo TQ-S and Xevo TQ-MS will include an increase in the number of concentration fields in the MassLynx sample list for use in TargetLynx from 20 (Conc A-T) to 50. SCN 997 is expected to be released in Q1 2021.

FIXED in SCN 997.