MassLynx 4.1 Inlet Editor fails to respond when clicking on the Column Manager shortcut - WKB5798

SYMPTOMS

• The ACQUITY Column Manager (CM) method parameters tab fails to open after clicking the CM shortcut icon on the left-hand pane from the LC inlet method editor (1D and 2D configuration)
• The message "InletEditor MFC Application Error" appears

Or

• The message "Inlet Method: Test: exception in Connect" appears
• The column manager can nevertheless be controlled via the MS console

ENVIRONMENT

• MassLynx 4.1 and 4.2
• Xevo TQ-S
• Xevo G2-XS QTof
• ACQUITY UPC2
• ACQUITY 2D Technology
• ACQUITY Column Manager (CM-A)
• ACQUITY Auxillary Column Manager
• Waters Pump Control software

CAUSE

The default.acm file is missing. This file should be located at C:\MassLynx\Default.pro\Acqudb. This is a software defect.

Alternatively, the default.acm file is present but corrupt.

FIX or WORKAROUND

Configure the inlet as a single-pump system, choose File > Save As and create a new Default.acm file, and then reconfigure the inlet back to a two-pump system.

Or

Obtain the Default.acm file from a different installation of MassLynx 4.1 (for example, SCN 855) and copy it to the system that has this issue.

ADDITIONAL INFORMATION

The issue was described as a reproducible software defect seen is specific SCNs, such as SCN 876 and SCN 905.

However, it has also been seen on SCN 1018 and SCN 1033 (to control LC-MS system including Xevo G2-XS QTof) with Waters Driver Pack 2021 Release 1 and Waters Driver Pack 2017 Release 2.

Use of the MassLynx repair function in the DM did not help.