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Problems using MassLynx on third-party Windows 10 processing PCs - WKB51388

Article number: 51388


  • MassLynx may freeze, hang, or fail to open
  • The Microsoft blue spinning circle (busy icon) may appeaar
  • An error message may appear:
    Microsoft Visual C++ Runtime Library
    Runtime Error!   
    Program C\MassLynx\mlynx4.exe   
    abnormal program termination



  • Windows 10 OS
  • MassLynx
  • Unsupported third-party laptops and PCs used for data processing only


Under investigation; please contact Waters Customer Service for more information


To minimize the risk of errors, reinstall MassLynx after configuring the PC as described below.

  1. Uninstall MassLynx.
  2. Set the User Account Control (UAC) to "Never Notify" (the lowest setting).
  3. UAC can be found by searching for UAC, or via Control Panel > System and Security.


  1. Confirm that the Java 5 folder is present at: C:\Program Files (x86)\Java\jre1.5.0_17. When MassLynx is installed, additional files are added to this folder. If the Java 5 folder is deleted or renamed, MassLynx attempts to re-install these files and displays the following message.

    This process will fail if the desktop user does not have local admin rights.
  2. Ensure that the laptop touch screen (if available) is disabled in Device Manager.     

  3. Copy the MassLynx installation files onto the hard disk of the destination PC.
  4. Install MassLynx from this locally saved copy.                                                                                                      

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