Positive Processing crashes during ChromaLynx Targeted Screening with error "ChromaLynx Identify MFC Application has stopped working" - WKB28555
SYMPTOMS
- Positive Processing crashes during the ChromaLynx Targeted Screening stage with the following error message:
ChromaLynx Identify MFC Application has stopped working
- The same error message appears if you perform just ChromaLynx Targeted Screening
- No results are generated
ENVIRONMENT
- MassLynx 4.1 and 4.2 releases for QTof or SYNAPT instrument control, such as SCN 923 (Xevo G2 XS Tof ) and SCN 851 SYNAPT G2-S
- ChromaLynx XS
- Targeted screening, in which the ChromaLynx Identify method references a target mass file (.txt)
CAUSE
The target mass file (referenced by the Identify method) contains fragment ion masses. However, the ChromaLynx XS application supplied in MassLynx releases for Tof and SYNAPT instrument control does not support ChromaLynx Fragment ion confirmation. The Identify method does not include the "Fragment ion confirmation" option. Under these circumstances, ChromaLynx processing crashes.
FIX or WORKAROUND
Remove all fragment ion masses from the referenced target mass file.
Or
Perform ChromaLynx processing on a separate processing-only PC that contains MassLynx Desktop, such as SCN 982. This recommendation is mentioned in the MassLynx SCN release notes. MassLynx Desktop supports ChromaLynx Fragment ion confirmation.
ADDITIONAL INFORMATION
id28555, CHROLYNX41, MLYNX, MLYNXV41, SCN851, SCN923, SCN982, SUPMM