Low MS sensitivity on QTof mass spectrometers - WKB91752

SYMPTOMS

• MS sensitivity is around three orders of magnitude lower than expected for leucine enkephaline (1E3 instead of 1E6) and other analytes.
• Occurs in both positive and negative resolution modes (customer is not using any other modes).
• Detector setup fails.

ENVIRONMENT

• SYNAPT G2-Si
• SYNAPT G2-S
• SYNAPT G2
• Xevo G2-XS Qtof
• Xevo G2-S Qtof
• Vion IMS QTof

CAUSE

Customer uses tune file created for troubleshooting a low-sensitivity problem on high m/z ions. In this tune file, the quad profile is set to a manual profile in both positive and negative resolution mode.

FIX or WORKAROUND

Set quad profile to auto profile or load a tune file with an auto quad profile.

ADDITIONAL INFORMATION