OBJECTIVE or GOAL
Achieve maximum sensitivity in positive ion mode and in negative ion mode on the Xevo TQ-XS.
- Xevo TQ-XS
1. in positive ion mode: increase Ion Energy 1 to -0.2 - 0.5 and Ion Energy 2 to 1.0 - 2.0
2. in negative ion mode: increase Ion Energy 1 to 0.5 - 1.0 and Ion Energy 2 to 1.0 - 2.0
The original Ion Energy settings, set by IntelliStart, do not always give best sensitivity on the long term. Upon utilization of the instrument, higher Ion Energy setting may be required to maintain optimal sensitivity. When one suspects a decrease in sensitivity it may be interesting to check the Ion Energy settings by infusing a compound. Using the sliders in the Tune page, one can optimize for best sensitivity. Increasing the Ion Energies too much may lead to spectral peak broadening. Therefore it is important to find a compromise between sensitivity and spectral resolution. Bear in mind that in most cases, Ion Energy settings are higher in negative ion mode compared to positive ion mode.