MS peak area increasing injection to injection over run - WKB52784

SYMPTOMS

• MS peak area increasing injection to injection over run.
• Method dependent.
• All ACQUITY diagnostics pass.
• Refreshing sample, mobile phase, and column did not resolve issue.

ENVIRONMENT

• XEVO TQ MS
• MassLynx
• Xevo TQD
• Xevo TQ-S

CAUSE

Charging effect caused by a dirty ion block and guide.

FIX or WORKAROUND

1. Clean ion block and guide following the appropriate Overview and Maintenance Guide.

ADDITIONAL INFORMATION

A dirty source enclosure can also cause this charging effect, so if cleaning the ion block, clean the source enclosure as well.