Poor QTof resolution on intact proteins or monoclonal antibodies (mAb) - WKB45630
Article number: 45630
SYMPTOMS
- Poor resolution (isotopic) on intact proteins or monoclonal antibodies (mAb)
- Poor resolution and intensity of charge state envelope
- Glycoforms are poorly resolved/defined
ENVIRONMENT
- Xevo QTof
- Xevo G2 QTof
- Xevo G2-S
- Xevo G2-XS
- Synapt HDMS
- SYNAPT G2-S
- SYNAPT G2-Si
- Vion IMS QTof
- ACQUITY RDa
- BioAccord
CAUSE
Insufficient vacuum—particularly due to a PM or vent
FIX or WORKAROUND
Allow the instrument to pump down for longer time (up to a week or more).
ADDITIONAL INFORMATION