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Waters

Poor QTof resolution on intact proteins or monoclonal antibodies (mAb) - WKB45630

Article number: 45630

SYMPTOMS

  • Poor resolution (isotopic) on intact proteins or monoclonal antibodies (mAb)
  • Poor resolution and intensity of charge state envelope
  • Glycoforms are poorly resolved/defined

ENVIRONMENT

  • Xevo QTof
  • Xevo G2 QTof
  • Xevo G2-S
  • Xevo G2-XS
  • Synapt HDMS
  • SYNAPT G2-S 
  • SYNAPT G2-Si
  • Vion IMS QTof
  • ACQUITY RDa
  • BioAccord

CAUSE

Insufficient vacuum—particularly due to a PM or vent

FIX or WORKAROUND

Allow the instrument to pump down for longer time (up to a week or more).

ADDITIONAL INFORMATION

 

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