Deconvolution reveals increased mass error on intact protein standard - WKB227896

SYMPTOMS

• Deconvolution of intact protein standard reveals increased mass error of, for example, 2 Da
• Historic data prove that a mass accuracy of 0.2 Da after deconvolution is possible on the specific protein standard
• Mass accuracy on small molecules meets specification

ENVIRONMENT

• MassLynx 4.2
• MaxEnt

CAUSE

Unknown sample issue

FIX or WORKAROUND

Double-check system performance using a Waters-certified protein standard (for example, 186004900 Mass Prep Std. or 186006552 Intact mAb Mass Check Std).

ADDITIONAL INFORMATION