How to adjust the quad resolution on a QTof for MSMS experiments - WKB22264

OBJECTIVE or GOAL

Reduce the resolution so that only the parent ion or isotope passes through the quad.

ENVIRONMENT

• Q-Tof Premier
• QTof micro
• QTof 2
• QTof
• Q-Tof Ultima API
• Q-Tof Ultima Global
• Synapt HDMS
• SYNAPT G2
• SYNAPT G2-S
• SYNAPT G2-Si
• Vion IMS QTof
• Xevo QTof
• Xevo Tof
• Xevo G2 QTof
• Xevo G2 Tof
• Xevo G2-S
• Xevo G2-XS

PROCEDURE

1. For Xevo or SYNAPT components, go into MSMS mode .
2. Adjust the LM Resolution from 4.7 or 4.9 to 14 or 15, in order to pass just a single isotope.

ADDITIONAL INFORMATION

The MSMS parameter LM resolution, which determines the mass range for the parent ion selection. For a 4K Quad the default is set to 4.7, which corresponds to a 3 m/z window. Setting this to 10 would give a narrower window of 1 m/z. Note that this may cause the intensity of the parent ion signal to decrease.