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Waters

Sodium adducts in much higher abundance than the protonated ion on SYNAPT G2-Si - WKB16747

Article number: 16747

SYMPTOMS

  • When infusing sample, see many more sodiated [M+Na]+ or [M+23]+ ions than protonated [M+H]+ or [M+1]+ ions
  • Peak of interest is 22 Da higher than expected for singly charged ions

ENVIRONMENT

  • SYNAPT G2
  • SYNAPT G2-S
  • SYNAPT G2-Si
  • Xevo TQD
  • Xevo TQ-MS
  • Xevo TQ-S
  • Xevo TQ-S micro
  • Xevo TQ-XS
  • Xevo QTof
  • Xevo G2
  • Xevo G2-S
  • Xevo G2-XS

CAUSE

High sodium, salt, or soap contamination in the source enclosure area

FIX or WORKAROUND

  1. Wipe down the source enclosure with methanol.
  2. Infuse 90/10 water/methanol + 1% formic acid.
  3. Clean the cone and baffle (if there is one).

ADDITIONAL INFORMATION

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