Sodium adducts in much higher abundance than the protonated ion on SYNAPT G2-Si - WKB16747

SYMPTOMS

• When infusing sample, see many more sodiated [M+Na]+ or [M+23]+ ions than protonated [M+H]+ or [M+1]+ ions
• Peak of interest is 22 Da higher than expected for singly charged ions

ENVIRONMENT

• SYNAPT G2
• SYNAPT G2-S
• SYNAPT G2-Si
• Xevo TQD
• Xevo TQ-MS
• Xevo TQ-S
• Xevo TQ-S micro
• Xevo TQ-XS
• Xevo QTof
• Xevo G2
• Xevo G2-S
• Xevo G2-XS

CAUSE

High sodium, salt, or soap contamination in the source enclosure area

FIX or WORKAROUND

1. Wipe down the source enclosure with methanol.
2. Infuse 90/10 water/methanol + 1% formic acid.
3. Clean the cone and baffle (if there is one).

ADDITIONAL INFORMATION