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ACQUITY UPLC H-Class Quaternary Solvent Manager (QSM) - Retention time shifts with tendency (earlier elution) - WKB88528

Article number: 88528

SYMPTOMS

  • Retention time shifts with trend toward earlier peak elution.
  • Subsequent injection shows earlier retention time (difference of 0.1-0.2 sec).

ENVIRONMENT

ACQUITY UPLC H-Class Quaternary Solvent Manager (QSM)

CAUSE

Blocked GPV low-pressure inline filters (700005173).

FIX or WORKAROUND

  1. Replace GPV low-pressure filters (700005173).
    1. Disconnect GPV to mixer tube fittings.
      clipboard_e9dc35a682623be5c27b55ebbd6de0655.png
    2. Take off old GPV low-pressure inline filters.
      clipboard_e78ae1471ebc735726b817f74b960e1af.png
    3. Replace with new GPV low-pressure inline filters.
      clipboard_ed390571952c7e45bb1b2899c4c5bd963.png
  2. Prime system.
  3. Run test injections to confirm RT shift resolution.

ADDITIONAL INFORMATION

 

gradient proportioning valve

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