ACQUITY UPLC H-Class Quaternary Solvent Manager (QSM) - Retention time shifts with tendency (earlier elution) - WKB88528

SYMPTOMS

• Retention time shifts with trend toward earlier peak elution.
• Subsequent injection shows earlier retention time (difference of 0.1-0.2 sec).

ENVIRONMENT

ACQUITY UPLC H-Class Quaternary Solvent Manager (QSM)

CAUSE

Blocked GPV low-pressure inline filters (700005173).

FIX or WORKAROUND

1. Replace GPV low-pressure filters (700005173).
   1. Disconnect GPV to mixer tube fittings.
      
   2. Take off old GPV low-pressure inline filters.
      
   3. Replace with new GPV low-pressure inline filters.
      
2. Prime system.
3. Run test injections to confirm RT shift resolution.

ADDITIONAL INFORMATION