How to replace the ACQUITY UPLC Column Manager switching-valve cartridge. - WKB85242

OBJECTIVE or GOAL

Replacing the column manager switching-valve cartridge.

ENVIRONMENT

• ACQUITY UPLC Column Manager

• ACQUITY UPLC H-Class PLUS

• ACQUITY UPLC H-Class PLUS Bio

• ACQUITY UPLC I-Class PLUS

PROCEDURE

1. In the console, select Column Manager from the system tree.
2. In the column manager information window, click Column Selection.
3. In the Column Manager Set Column dialog box, select Waste *
4. Pull the valve forward, approximately 2 cm, and rotate the lock ring clockwise until it rests against the lock ring stop.
5. Use the 1/4-inch wrench to remove the fittings attached to the switching-valve cartridge.
6. Rotate the lock ring counterclockwise and use the 2-mm hex wrench to remove the hex
   screw at the 10 o’clock position on the switching-valve cartridge.
7. Remove the switching-valve cartridge from the switching-valve assembly by pulling the
   cartridge straight forward.
8. Unpack the new switching-valve cartridge.
9. Ensure that the groove in the cartridge housing aligns with the groove on the drive clamp.
10. Insert the new switching-valve cartridge into the switching-valve cartridge chamber.
11. Insert the 2-mm hex screw at the 10 o’clock position on the switching-valve cartridge and
    tighten the screw using the 2-mm hex wrench.
12. Pull the valve forward, approximately 2 cm, and rotate the lock ring clockwise until it rests
    against the stopper.
13. Use the 1/4-inch wrench to reattach all fittings and tighten them 1/4-turn beyond finger-tight
    for existing fittings, or 3/4-turn beyond finger-tight for new fittings.
14. Rotate the lock ring counterclockwise to the 12 o’clock position.
15. Push the switching-valve assembly in until it stops.
16. Ensure that the tubing is properly oriented so that the column compartment door is
    unobstructed when closed.

* If the column manager has been configured with Advanced settinge eg use as a diverter valve, the Waste will not be an option therefore select Position 2 (waste)

ADDITIONAL INFORMATION

Refer to page 93 of the ACQUITY UPLC Column Manager - Active (CM-A) and Column Manager - Auxiliary (CM-Aux) for further information.