- Low (or zero) pressure
- Erratic pressure
- Loss of prime resulting in no solvent flow
- ACQUITY Arc
- ACQUITY Arc Bio
- ACQUITY Arc QSM-R
- ACQUITY Arc Bio QSM-R
The check valves are blocked, clogged, or have residues that prevent efficient operation.
The issue generally affects the primary check valve but may also affect the accumulator check valve.
FIX or WORKAROUND
- Sonicate or replace the affected check valves.
- Perform a dynamic leak test of the pump to confirm fluidics integrity.
Part numbers of check valves to replace:
Primary check valve (standard): 700010664
Primary check valve (Bio): 700010642
Primary check valve (THF/Hexane): 700011074
Accumulator DBS check valve (standard): 700005164
Accumulator DBS check valve (Bio): 700005415
Accumulator DBS check valve (THF/Hexane): 700005273
These issues are predominantly caused by use in applications that employ relatively high concentrations of nonvolatile buffer salts in the mobile phases—typically applications taken from pharmacopeias (USP/Ph.Eur./JP, etc.).
When using such procedures, it is recommended that the system be flushed and cleaned regularly to remove excess buildup of buffer salts, which can result in pressure issues at various locations within the system.
If this issue is observed in situations where pharmacopeial applications are being used with buffered mobile phases, please add any available application details to the CIT record. Such information is beneficial in determining causes of failures and driving product improvements.
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