Poor peak area precision with 2424 ELSD - WKB64193

SYMPTOMS

• Peak area varies from injection to injection, high % RSD, poor reproducibility.
• Peak shape inconsistent at apex
• Lower than usual sensitivity

ENVIRONMENT

• 2424 ELS Detector
• ACQUITY UPLC ELS Detector

CAUSE

Nebulizer is going bad, giving poor spray.

FIX or WORKAROUND

If cleaning (WKB77718) the nebulizer is unsuccessful replace the 2424 nebulizer (205001124 - Standard High-Flow) or ACQUITY ELSD nebulizer (205000342).

ADDITIONAL INFORMATION

If the system is qualified, replacement of the nebulizer requires ELSD requalification of the detector tests.