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Waters

Poor reproducibility on H-Class - WKB48003

Article number: 48003

SYMPTOMS

  • Intermittently poor reproducibility (% RSD) based on peak area and height for an established customer method
  • All system diagnostics pass
  • System SQT precision tests pass

ENVIRONMENT

  • Empower
  • ACQUITY UPLC H-Class

CAUSE

The use of methanol as sample diluent causes high variability with default sample manager settings.

FIX or WORKAROUND

Change the sample draw rate to 150 µL/min and add a 0.2-µL post-draw air gap.

ADDITIONAL INFORMATION

 

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