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Waters

High area %RSD for ACQUITY UPLC - WKB46773

Article number: 46773

SYMPTOMS

  • High %RSD for area counts
  • No bubbles in sample syringe
  • All ACQUITY Sample Manager- Fixed Loop diagnostics pass
  • No leaks observed
  • New column
  • New standards
  • Stable delta while flowing
  • Partial Loop Needle Overfill (PLNO) injection method
  • New needle, needle seal, and loop

ENVIRONMENT

  • ACQUITY Sample Manager - Fixed Loop

CAUSE

  • Faulty column stabilizer

FIX or WORKAROUND

  1. Perform replicate injections of known standard with an altered SM-FL method for full-loop injections.
  2. If full-loop injections pass %RSD, replace the column stabilizer (205000291 for 50- to 100-mm columns).

ADDITIONAL INFORMATION

 

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