- System pressure high
- Leaks from the finger-tight fittings on the post-column valve in the column manager
- ACQUITY UPLC Column Manager
If any of the tubing connected from the column manager outlet onward is over-tightened, back pressure builds excessively, making the post-column valve finger-tight connections leak.
FIX or WORKAROUND
- Trim the tube ends or replace the tubing completely.
- Remake the connections.