Low sensitivity or blank chromatograms but signal as expected when using direct infusion - WKB240722
Article number: 240722
SYMPTOMS
- Low sensitivity or blank chromatograms but signal as expected when using direct infusion
- Passes sample syringe leak test
- Fails needle seal readiness test
ENVIRONMENT
- MassLynx
- Empower
- UNIFI
- ACQUITY UPLC H-Class
- ACQUITY UPLC I-Class
-
Quadrupole MS
-
Tof MS
CAUSE
The needle seal is worn and the needle no longer makes a good seal.
FIX or WORKAROUND
- Characterize needle seal.
- Run the needle seal readiness test.
ADDITIONAL INFORMATION
id240722, UPIBSM, UPIBSM+, UPISMFL, UPISMFL+, UPISMFTIVD, UPISMFTN, UPISMFTN+, UPQSM, UPQSM+, UPQSMBIO, UPQSMBIO+, UPSMFTN, UPSMFTN+, UPSMFTNB+, UPSMFTNBIO