Peak integration in TargetLynx results cuts off the bottom of the peak - WKB69746

SYMPTOMS

• Peak integration in TargetLynx results is incorrect
• Integration baseline is about one third the way up the peak
• Bottom part of the peak is cut off or excluded from the integration

ENVIRONMENT

• MassLynx
• TargetLynx

CAUSE

The retention time window setting in the TargetLynx method is too narrow.

FIX or WORKAROUND

1. Measure the width of the peak at the base in the Chromatogram view.
   • Open the chromatogram and display the specific MRM trace.
   • Zoom in on the peak of interest.
   • Hold down the right mouse button and drag across the base of the peak.
   • Continue to hold the right mouse button and take note of the time shown in the lower-left corner of the Chromatogram view.
2. Divide this number by 2 and add about 10%.
3. Type this result into the Retention Time Window setting on the Compound Properties page of the TargetLynx method for this compound.
4. Set the Locate Peak Selection setting to Largest.
5. Reprocess the dataset.

ADDITIONAL INFORMATION