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What is the correct half-height multiplier for USP signal-to-noise calculation in Empower 3 Feature Release 2? - WKB69117

Article number: 69117

ENVIRONMENT

  • Empower 3 Feature Release 2
  • USP Signal to Noise (s/n)
  • Regional Pharmacopoeia

ANSWER

In Empower 3 Feature Release 2, the default half-height multiplier for USP (and EP) s/n Region is 5.

ADDITIONAL INFORMATION

See the Technical Note Signal-to-Noise Values in Empower 3.

There was a calculation change as of Empower 3 Feature Release 2.

See a discussion of the history of s/n calculations on page 5. At the bottom of page 5, as of Empower 3 FR2: 
"USP s/n is still calculated as 2H/h, but the determination of H and h has been changed to match the EP and JP s/n calculations. The default width of the region used to calculate h (the half-height multiplier) remains at 5. EP s/n is also still calculated as 2H/h, but the default width of the region used to calculate h (the half-height multiplier) is now 5 instead of 20."

So, as of FR2, the default half-height multiplier for USP and EP s/n Region is 5.

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