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What formulas does Empower use to calculate relative resolution for System Suitability? - WKB52882

Article number: 52882

ENVIRONMENT

  • Empower 3
  • System Suitability
  • Regional pharmacopeia

ANSWER

The formulas are described in the Empower System Suitability Quick Reference Guide (71500031605), which can be downloaded from the Waters website. See section 3.6 for details.

The specific resolution equation used to calculate relative resolution depends on your Pharmacopeia choice on the System Suitability tab of the Processing Method window. The four Pharmacopeia options are US Pharmacopeia (USP), European Pharmacopeia (EP), Japanese Pharmacopeia (JP), and "All".

  • Selecting "All" calculates relative resolution using peak widths at baseline between tangent lines (Figure 3.16)
  • Selecting USP, EP, or JP calculates relative resolution using peak widths at half height (Figures 3.17 and 3.18)

 

 

USP.png

USPHH.png

 

JP_EP.png

ADDITIONAL INFORMATION

 

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