What are some common causes of peak fronting? - WKB255705
Article number: 255705
ENVIRONMENT
- Columns
- Liquid chromatography
ANSWER
Common causes include:
- Mass overload (too much mass in each injection)
- Column void due to packing material dissolution or bed collapse
- Volume overload (too much sample volume injected)
- Poor connection somewhere in the flow path between the injector and the detector:
- If using PEEK fittings, the tubing can slip if the PEEK finger-tight fitting does not grip the tubing strongly enough.
- If using stainless steel fittings, ferrule depth may be too short and a new connection may need to be made.
ADDITIONAL INFORMATION
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