What reverse-phase column chemistry is recommended for oligonucleotides greater than 60 mer in length? - WKB108369
Article number: 108369
ENVIRONMENT
- Reverse-phase chemistry
- Oligonucleotides
- BEH300 C18
ANSWER
The reverse-phase column chemistry recommendation for oligonucleotides longer than 60 mer is BEH300 C18: ACQUITY UPLC BEH300 C18 in 1.7 µm particle size and XBridge BEH300 C18 in 2.5 µm particle size.
ADDITIONAL INFORMATION
For additional information, see Oligonucleotide Separation Technology XBridge OST C18 Columns Method Guidelines, Oligonucleotide Separation Technology ACQUITY UPLC C18 Column Method Guidelines, or Hexylammonium Acetate as an Ion-Pairing Agent for IP-RP LC Analysis of Oligonucleotides
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