What is the reason not to top off mobile phases such as THF? - WKB238495
Article number: 238495
ENVIRONMENT
- Gel Permeation Chromatography (GPC)
- Alliance
- Mobile phases
- Maintenance
- Advanced Polymer Chromatography (APC)
ANSWER
Tetrahydrofuran (THF) is a common Cat B Peroxide Former (PF). THF generates peroxides that are sensitive and energetic if detonated. These peroxides may accumulate to concentrations high enough to have noticeably higher viscosity or to form a separate liquid phase.
ADDITIONAL INFORMATION
Many compounds solubilize in THF, allowing contaminants to concentrate over time if recycled.
