No MSMS beam on a QTof - WKB3503

SYMPTOMS

• There is a beam in MS mode
• There is no beam in MSMS mode
• Increasing the ion energy value can restore MSMS beam, although signal intensity is weaker than expected
• MSMS beam restored by reducing LM or HM res
• Rectified RF at expected value
• Quad DC voltages at expected values
• No sample ions observed in TOF MSMS mode
• Strong beam present in TOF MS mode
• MSMS beam restored by reducing LM or HM res
• Rectified RF at expected value
• Quad DC voltages at expected values

ENVIRONMENT

• SYNAPT G1 QTof
• Xevo G2 QTof
• Q-Tof Premier
• Xevo QTof
• Xevo G2-S
• Xevo G2-XS
• Vion IMS QTof

CAUSE

The quad settings are at the default values

This happens if they were not set after a software reload or upgrade

FIX or WORKAROUND

1. Find the quad settings from a previous PM, installation or screen capture. 
2. In the tune page, enable System View (Setup -> System View -> password = access).
3. Go to the Quadrupole tab and select adjust.
4. Change the quad settings values accordingly in the MS tune page.
5. Save the quad settings.
6. Check for an MSMS beam.
7. Run ion transmission test(s) as per the Quad PCB technical reference sheet document, 715002478 (see Quad check procedure).
8. Save the system settings within EPC and host PC.

ADDITIONAL INFORMATION

If you cannot find the original quad settings, contact your local Waters Technical Service or manually tune the quad per the appropriate instrument technical reference sheet.

Once you obtain the quad settings are obtained, print or save the settings in a suitable location.