ACQUITY TUV baseline is unstable and drifting upward, affecting peak integration - WKB4110

SYMPTOMS

• High background noise
• Interference prevents suitable peak integration

Other observations:

• New column, chemistry, and mobile phase
• Detector noise and drift test passes successfully
• System pressure is stable
• The pump leak diagnostics pass
• Back pressure regulator is installed
• The filter time constant is programmed correctly
• System was flushed according to cleaning protocol
   

ENVIRONMENT

• H-Class System
• TUV Detector
• Solvent A: 90/10 H₂O/CH₃CN
• Solvent B: 95/5 CH₃CN/THF
• Wash: 70/15/15 H₂O/CH₃CN/2-propanol
• Purge and Seal Wash: 90/10 H₂O/CH₃CN

CAUSE

 The solvent bottles are dirty and contaminated.

FIX or WORKAROUND

Replace all glassware. Use brand new solvent bottles and freshly prepared solvents.

ADDITIONAL INFORMATION