- Pressure fluctuations
- Pump recently underwent PM
- ACQUITY H-Class Quaternary Solvent Manager (QSM)
Solvent lines are not properly primed.
FIX or WORKAROUND
- Ensure all lines have enough solvent in the bottle
- Prime all solvent lines for at least 3 mins per line.
- Attached suitable column to system.
- Slowly ramp to initial conditions and allow system pressure to stabilize for at least 10 mins