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Pressure fluctuations on ACQUITY UPLC H-Class QSM after PM - WKB28335

Article number: 28335

SYMPTOMS

  • Pressure fluctuations
  • Pump recently underwent PM

ENVIRONMENT

  • ACQUITY H-Class Quaternary Solvent Manager (QSM)

CAUSE

Solvent lines are not properly primed.

FIX or WORKAROUND

  1. Ensure all lines have enough solvent in the bottle
  2. Prime all solvent lines for at least 3 mins per line.
  3. Attached suitable column to system.
  4. Slowly ramp to initial conditions and allow system pressure to stabilize for at least 10 mins 

ADDITIONAL INFORMATION

 

pressure ripple

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