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Waters

No peaks and poor chromatography on an H-Class system - WKB24767

Article number: 24767

SYMPTOMS

  • No peak for caffeine sample
  • No peaks running the gradient test
  • Pressure trace does not change with gradient changes for AB and CD
  • Pump and system leak tests fail
  • Peaks returned with GPV replacement show tailing and lower sensitivity
  • Peaks missing again after I2V check valve replacement and primary head rebuild
  • Peaks return with removal of sample loop
  • Wash of system with phosphoric acid shifts retention times

ENVIRONMENT

  • ACQUITY UPLC H-Class

CAUSE

Injection valve leaks to waste during injections.

FIX or WORKAROUND

Replace the injection valve cartridge (700005236).

ADDITIONAL INFORMATION

 

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