LC-MS system loses communication overnight - WKB248286

SYMPTOMS

• Connection to the MS and LC components are lost overnight
• Errors in ACQUITY Console indicate lost communication for both UPLC and MS
• Tune page unresponsive, requiring reboot of PC and MS
• Time stamp for Console errors corresponds to Windows Event System log errors, which include "windows power setting" 

ENVIRONMENT

• MassLynx
• ACQUITY UPLC H-Class
• Xevo TQ-S micro

CAUSE

PC has "sleep after 5 hours" enabled.   

FIX or WORKAROUND

Configure the PC to "never sleep".

ADDITIONAL INFORMATION