TargetLynx calculates the wrong concentration for analytes - WKB23320
Article number: 23320
SYMPTOMS
- The standard concentrations look good and the calibration curve looks good
- Concentrations are calculated for the analytes, but for the same response in the standard the analyte is given a much higher concentration
ENVIRONMENT
- TargetLynx
- MassLynx
CAUSE
A different amount of internal standard was used in the standards than in the analytes, and the TargetLynx method is using a fixed concentration for the internal standard. So it is expecting the same internal standard response for every sample, regardless of whether it is a sample or analyte.
FIX or WORKAROUND
Remake the samples (standards and analytes) with the same amount of internal standard.
OR
- Add a Conc column (for example, Conc B) to the sample list.
- Fill in the Internal Standard concentration for each sample in the sample list.
- Open the TargetLynx method and go to the calibration properties page for the internal standard.
- Change the concentration of the standard level from fixed to Conc B, and save the method.
- Reprocess the samples.
ADDITIONAL INFORMATION
id23320, MLYNX, MLYNXV41, SUPMM, TARLYNX41